Athletes who are more advanced or weigh more than 220 pounds can increase the dosage to 150 mg/day in the third week. This dosage, however, should not be taken for periods longer than two to three weeks. Following, the dose should be reduced by one tablet every week. Since Anadrol 50 quickly saturates the receptors, its intake should not exceed six weeks. The dramatic mass build up which often occurs shortly after administration rapidly decreases, so that either the dosage must be increased (which the athlete should avoid due to the considerable side effects) or, even better, another product should be used. Those who take Anadrol 50 for more than 5-6 weeks should be able to gain 20 – 25 pounds. These should be satisfying results and thus encourage the athlete to discontinue using the compound.
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There is limited information available on the pharmacokinetics of oxymetholone.  It appears to be well-absorbed with oral administration .  Oxymetholone has very low affinity for human serum sex hormone-binding globulin (SHBG), less than 5% of that of testosterone and less than 1% of that of DHT.  The drug is metabolized in the liver by oxidation at the C2 position, reduction at the C3 position, hydroxylation at the C17 position, and conjugation .   The C2 hydroxymethylene group of oxymetholone can be cleaved to form mestanolone (17α-methyl-DHT), which may contribute to the effects of oxymetholone.  The elimination half-life of oxymetholone is unknown.  Oxymetholone and its metabolites are eliminated in the urine .