Post-cycle therapy consists of a drug called a SERM, or Selective Estrogen Receptor Modulator. These drugs serve two purposes. First, they help to combat the effects of excess estrogen, which is beneficial in preventing estrogenic side effects like gynecomastia and weight gain after your cycle. More importantly, they stimulate the production of LH and FSH, easing your body back into natural testosterone production in mere days rather than weeks, months, or years. Failing to use a SERM could result in fat gain, muscle loss, and even testicular atrophy. For this reason, post-cycle therapy is a requirement – especially for men.
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Metabolic side effects have included osteolytic-induced hypercalcemia in immobilized patients or those with metastatic breast disease. Anabolic steroids affect electrolyte balance, nitrogen retention, and urinary calcium excretion. Edema, with and without congestive heart failure, has occurred during anabolic steroid therapy. Decreased glucose tolerance requiring adjustments in hyperglycemic control has been noted in diabetic patients. The androgenic activity of anabolic steroids may decrease levels of thyroxin-binding globulin and result in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction. Significant increases in low density lipoproteins (LDL) and decreases in high density lipoproteins (HDL) have occurred. [ Ref ]