The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.
When Anavar was first brought to market, various medical studies were conducted by the US Government, and partly by Savient who manufactured Anavar back in the 1960’s. Moderate Oxandrolone dosages were given to elderly subjects above 60 who were not active which showed promising results. The study indicated that men gain muscle mass and lose fat mass if they take Anavar for 12 weeks. It also showed that 12 weeks following the studies end, the muscle mass was lost. What it did show was that the fat mass lost during this administration period, did stay away.