Oxandrolone and wound healing

The following factors were checked:

  • a. Fatigue was measured objectively through increases in pulse of over 75% of predicted maximum (based on age) and a respiratory rate exceeding 30 breaths per minute beyond one minute after completion of the activity.
  • b. Muscle function was quantitated using a physical therapy index. The physical therapy program was determined for each patient by the burn therapist team based on optimum projected goals to be achieved at the three week period. Standard isokinetic and resistance exercises were used to increase strength. Ambulation, stair climbing and the stationary bike were used to increase endurance. Since the basic components of therapy programs were nearly identical between patients, an index was developed which quantitated progress of patient performance:

This study is designed to determine whether the use of oxandralone, an anabolic steroid, can heal pressure ulcers in persons with spinal cord injury (SCI). In a Feasibility Study, three VA SCI Units will screen and randomize patients into treatment with oxandralone or with placebo. Eleven other sites will screen patients to determine eligibility but will not treat patients with the agent. Following the Feasibility Study, all sites will participate in a blinded, randomized treatment study. A total of 400 patients will be enrolled over a four-year period. Any patient in a participating unit who has chronic SCI and a difficult-to-heal pelvic ulcer will be eligible for the study if other entry criteria are met. All enrolled patients will be followed for a period of 24 weeks to determine whether their target pressure ulcers heal. Those who are healed will be followed for an additional four weeks to determine whether the ulcer remains healed.

Oxandrolone and wound healing

oxandrolone and wound healing

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