As a very mild anabolic steroid Oxandrolone is not well-suited for bulking cycles or gaining phases; you will not produce a vast amount of lean muscle tissue through its use when speaking of performance enhancing purposes; however, what is produced will be solid muscle tissue. This simply means Oxandrolone has the ability to not only aid in reducing body-fat but preserving muscle tissue while on a calorie restricted diet; further, the more muscle tissue we have the greater our metabolic activity will be thereby increasing the rate in-which body-fat is utilized for energy.
The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns. These effects are mediated, in part, by the androgen receptor (AR). Anti-glucocorticoid effects have also been reported for some anabolic steroids, and the goal of our studies was to determine whether oxandrolone had a similar mechanism of action. Studies with in vitro translated glucocorticoid receptor (GR), however, showed no inhibition of cortisol binding by oxandrolone. Conversely, experiments in cell culture systems demonstrated significant antagonism of cortisol-induced transcriptional activation by oxandrolone in cells expressing both the AR and GR. Inhibition was not overcome by increased cortisol concentration, and no inhibition by oxandrolone was observed in cells expressing GR alone, confirming that non-competitive mechanisms were involved. AR-dependent repression of transcriptional activation by oxandrolone was also observed with the synthetic glucocorticoids dexamethasone and methylprednisolone. Furthermore, the AR antagonists 2-hydroxyflutamide and DDE also repressed GR transactivation in an AR-dependent manner. A mutant AR lacking a functional nuclear localization signal (AR 4RKM ) was active in oxandrolone-mediated repression of GR even though oxandrolone-bound AR 4RKM failed to enter the nucleus and did not affect nuclear import of GR. These data indicate a novel action of oxandrolone to suppress glucocorticoid action via crosstalk between AR and GR.
It has some mild side effects associated with it as well. Side effects occur when you take it for a very long period of time and in more quantity. Major drawback of Anavar is that it is too costly, although available in black market but one cannot be so sure of the authenticity of it bought from there. As it is DHT and due to this hair loss and acne can occur. But hair loss only in men who have got this hair loss disease genetically transmitted. There could be high blood pressure and high cholesterol levels but only for those who are not living a healthy life style and these diseases are not transmitted genetically to the users as well. Due to the non aromatizing nature of Anavar it has taken side effects of water retention and Gynecomastia out of the equation.