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Five cases of hepatotoxicity or liver failure , two of which resulted in death, have been reported with bicalutamide.   Symptoms that may indicate liver dysfunction include nausea, vomiting, abdominal pain, fatigue, anorexia , "flu-like" symptoms , dark urine , and jaundice .  Bicalutamide has also been associated with several case reports of interstitial pneumonitis , which can potentially progress to pulmonary fibrosis .    Symptoms that may indicate lung dysfunction include dyspnea (difficult breathing or shortness of breath), cough, and pharyngitis ( inflammation of the pharynx , resulting in sore throat ).  Both hepatotoxicity and interstitial pneumonitis are said to be extremely rare events with bicalutamide.    A few cases of photosensitivity have been reported with bicalutamide.  Hypersensitivity reactions ( drug allergy ) like angioedema and hives have also uncommonly been reported in association with bicalutamide.  Because it is an antiandrogen, bicalutamide has a theoretical risk of birth defects like ambiguous genitalia and brain feminization in male fetuses .    
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